There are certain planets as per that are responsible for bringing miseries to a natives life, if positioned/aligned in a negative way in the birth chart. The most dreaded planets in that sense are- Saturn, Mars, Rahu and Ketu. While there are many planetary placements or combinations that prove to be beneficial, there are some ill placements of planets that cause a Dosh or a Flaw in the horoscope resulting in severe problems. Two such Doshas are- Kaal Sarp Dosh and Manglik Dosh (or Mangal Dosha).
Manglik Dosh arises with the ill placement of planet Mars and if present in both or even either of the married couples horoscope, it destroys their marital bliss. Manglik Dosha in some cases if not treated timely and properly, can even result into the death of ones spouse. Another deadly combination that might appear in a natives horoscope is called the Kaal Sarp Dosh. "Kaal" in this context is Death and "Sarp" is Snake.